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航空公司不正常航班管理——模型和解决方法综述 Review

苏艺, 谢可欣, 王洪建, 梁哲, Wanpracha Art Chaovalitwongse, Panos M. Pardalos

《工程（英文）》 2021年 第7卷 第4期   页码 435-447 doi: 10.1016/j.eng.2020.08.021

摘要：

航班的正常运行可能会受到各种不可预测因素的影响，导致如机场关闭、临时飞机维护等不正常航班情况发生。当不正常航班产生时，航空公司运行控制中心会采取多种方法来调整资源（包括航班时刻、飞机和机组等）的分配并重新安排旅客以实现航班计划的恢复。本文首先介绍了不正常航班生成的可能场景和一系列常见的恢复手段，接着回顾了飞机路径恢复、机组恢复和多资源整合恢复的基本模型和相关扩展研究，旨在为航空公司实际运行中不同的恢复场景提供合适的模型和方法。此外，本文还对相关课题的未来研究方向提出了建议。

关键词： 不正常航班管理     飞机路径恢复问题     机组恢复问题     多资源整合恢复问题    

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Two-stage stochastic programming with robust constraints for the logistics network post-disruption response

《工程管理前沿（英文）》   页码 67-81 doi: 10.1007/s42524-022-0240-2

摘要： Logistics networks (LNs) are essential for the transportation and distribution of goods or services from suppliers to consumers. However, LNs with complex structures are more vulnerable to disruptions due to natural disasters and accidents. To address the LN post-disruption response strategy optimization problem, this study proposes a novel two-stage stochastic programming model with robust delivery time constraints. The proposed model jointly optimizes the new-line-opening and rerouting decisions in the face of uncertain transport demands and transportation times. To enhance the robustness of the response strategy obtained, the conditional value at risk (CVaR) criterion is utilized to reduce the operational risk, and robust constraints based on the scenario-based uncertainty sets are proposed to guarantee the delivery time requirement. An equivalent tractable mixed-integer linear programming reformulation is further derived by linearizing the CVaR objective function and dualizing the infinite number of robust constraints into finite ones. A case study based on the practical operations of the JD LN is conducted to validate the practical significance of the proposed model. A comparison with the rerouting strategy and two benchmark models demonstrates the superiority of the proposed model in terms of operational cost, delivery time, and loading rate.

关键词： logistics network design     post-disruption response strategy     two-stage stochastic programming     conditional value at risk     robust constraint    

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Modeling of the resilient supply chain system from a perspective of production design changes

《工程管理前沿（英文）》   页码 96-106 doi: 10.1007/s42524-022-0235-z

摘要： Building an effective resilient supply chain system (RSCS) is critical and necessary to reduce the risk of supply chain disruptions in unexpected scenarios such as COVID-19 pandemic and trade wars. To overcome the impact of insufficient raw material supply on the supply chain in mass disruption scenarios, this study proposes a novel RSCS considering product design changes (PDC). An RSCS domain model is first developed from the perspective of PDC based on a general conceptual framework, i.e., function-context-behavior-principle-state-structure (FCBPSS), which can portray complex systems under unpredictable situations. Specifically, the interaction among the structure, state and behavior of the infrastructure system and substance system is captured, and then a quantitative analysis of the change impact process is presented to evaluate the resilience of both the product and supply chain. Next, a case study is conducted to demonstrate the PDC strategy and to validate the feasibility and effectiveness of the RSCS domain model. The results show that the restructured RSCS based on the proposed strategy and model can remedy the huge losses caused by the unavailability of raw materials.

关键词： resilient supply chain     supply chain disruption     domain modeling     product design changes    

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Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 433-440 doi: 10.1007/s11783-013-0594-0

摘要： Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O-deethylase (EROD) assay using H4IIE cells for aryl hydrocarbon receptor (Ah-R) agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities (0.9 ng E2·g to 6.8 ng E2·g , dw), but relative higher androgen receptor antagonistic activities (nd to 45%), progestin receptor antagonistic activities (nd to 80%) and Ah-R agonistic activities (1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)·g , dw) were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol (E2) equivalent quantity (EEQ) level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodibenzo- -dioxin toxic equivalent quantity (TEQ) level of sewage sludge composted was much lower than that of sewage sludge.

关键词： sewage sludge     in vitro bioassay     endocrine disruption     dioxin-like effect    

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Enhanced production of

Shen Huang,Xudong Feng,Chun Li

《化学科学与工程前沿（英文）》 2015年 第9卷 第4期   页码 501-510 doi: 10.1007/s11705-015-1544-0

摘要： -Glucuronidase from Li-3 (PGUS) can efficiently hydrolyze glycyrrhizin into the more valuable glycyrrhetic acid monoglucuronide. However, a low productivity of PGUS and the lack of an effective separation strategy have significantly limited its industrial applications. Therefore, the production of PGUS has been improved by optimizing both the fermentation and purification strategies. A two-stage fermentation strategy was developed where PGUS was first grown with glucose and then PGUS was produced in the presence of glycyrrhizin as an inducer. By using this strategy, the biomass was increased 1.5 times and the PGUS activity increased 5.4 times compared to that when glycyrrhizin was used as the sole carbon source. The amount of PGUS produced was increased another 16.6% when the fermentation was expanded to a 15-L fermenter. An effective protocol was also established to purify the PGUS using a sequential combination of hydrophobic, strong anion-exchange and gel filtration chromatography. This protocol had a recovery yield of 6% and gave PGUS that was 39 times purer than the crude PGUS. The purified PGUS had a specific activity of 350 U·mg .

关键词： β-glucuronidase     glycyrrhetic acid monoglucuronide     cell disruption     purification     chromatography    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 554-562 doi: 10.1007/s11684-017-0543-6

摘要：

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.

关键词： CAR-T     CRISPR-Cas9     LAG-3    

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Simultaneous harvesting and cell disruption of microalgae using ozone bubbles: optimization and characterization

Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee

《化学科学与工程前沿（英文）》 2021年 第15卷 第5期   页码 1257-1268 doi: 10.1007/s11705-020-2015-9

摘要： In the present study, ozone was introduced as an alternative approach to harvest and disrupt microalgae cells ( ) simultaneously for biodiesel production. At the optimum ozonation conditions (6.14 g·h ozone concentration, 30 min ozonation time, 1 L·min of ozone flowrate at medium pH of 10 and temperature of 30 °C), the sedimentation efficiency of microalgae cells increased significantly from 12.56% to 68.62%. It was observed that the microalgae cells aggregated to form flocs after pre-treated with ozone due to the increment of surface charge from –20 to –6.59 mV. Besides, ozone had successfully disrupted the microalgae cells and resulted in efficient lipid extraction, which was 1.9 times higher than the control sample. The extracted microalgae lipid was mainly consisted of methyl palmitate (C16:0), methyl oleate (C18:1) and methyl linolenate (C18:3), making it suitable for biodiesel production. Finally, utilization of recycled culture media after ozonation pre-treatment showed robust growth of microalgae, in which the biomass yield was maintained in the range of 0.796 to 0.879 g·h for 5 cycles of cultivation.

关键词： microalgae     biodiesel     ozonation     pre-treatment     lipid    

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Metro train rescheduling by adding backup trains under disrupted scenarios

Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU

《工程管理前沿（英文）》 2017年 第4卷 第4期   页码 418-427 doi: 10.15302/J-FEM-2017044

摘要： In large cities with heavily congested metro lines, unexpected disturbances often occur, which may cause severe delay of multiple trains, blockage of partial lines, and reduction of passenger service. Metro dispatchers have taken a practical strategy of rescheduling the timetable and adding several backup trains in storage tracks to alleviate waiting passengers from crowding the platforms and recover from such disruptions. In this study, we first develop a mixed integer programming model to determine the optimal train rescheduling plan with considerations of in-service and backup trains. The aim of train rescheduling is to frequently dispatch trains to evacuate delayed passengers after the disruption. Given the nonlinearity of the model, several linearization techniques are adapted to reformulate the model into an equivalent linear model that can be easily handled by the optimization software. Numerical experiments are implemented to verify the effectiveness of the proposed train rescheduling approach.

关键词： train rescheduling     backup train     metro line     disruption     timetable    

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Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption

《工程管理前沿（英文）》   页码 158-170 doi: 10.1007/s42524-022-0238-9

摘要： Omnichannel retailing strategies are widely used in practice and have been extensively studied in recent years, but few studies have explored omnichannel retailing operations in response to supply disruption in the post-pandemic era. To fill this gap, this study explores whether the adoption of omnichannel fulfillment options (i.e., ship-from-store and ship-to-store options) can mitigate the risk of supply disruption in a supply chain where a retailer orders products from a reliable supplier and a risky supplier, respectively. Under the omnichannel retailing strategy, the retailer’s order quantity from the risky supplier may increase or decrease while that from the reliable supplier may increase. Interestingly, it is possible to achieve a win–win–win outcome when the supply disruption risk is high and the market share of the channel offered by the risky supplier is low. Moreover, the entire supply chain benefits from the omnichannel retailing strategy even if it faces a high level of disruption risk.

关键词： supply chain disruption     omnichannel fulfillment option     ship-from-store     ship-to-store    

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The Routine and Emergency Coordinated Management of Public Security

Ning Liu

《工程管理前沿（英文）》 2015年 第2卷 第4期   页码 331-338 doi: 10.15302/J-FEM-2015063

摘要： The paper presents a study based on the observation of public security programme situations. Nowadays, public security management is faced with challenges such as the increase in non-traditional safety threats, high occurrence probability, obvious complex chain reactions, high security demand, vulnerable bearing systems and world-wide influences. For the new adapted requirements of public security management, this paper puts forward the concept of the coordinated routine and emergency management, which combines the routine management at normal status and the emergency management at the abnormal status based on the whole process of public security management. This paper analyzes the coordinated management system and establishes the decision-making objectives, decision-making model and constraints. In addition, this paper proposes the basic strategy of achieving the coordinated management of public security.

关键词： public security     routine management     emergency management     coordinated management    

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Inheritance and Innovation of Engineering Management Informatization

Kai Sun,Ren-huai Liu

《工程管理前沿（英文）》 2014年 第1卷 第1期   页码 76-82 doi: 10.15302/J-FEM-2014014

摘要： In the life-cycle of large projects, the operational phase lasts the longest, costs the most and substantially benefits the project. During the whole phase, energy, material and human resources may cost a lot. Effective control of such costs is one of the main targets of engineering management informatization. How to lower the organization collaboration cost in project management and how to support effective collaboration among different areas, organizations and departments in the ways of technology and management are major goals in engineering management informatization. In the phase of project operation, project owners, partners and customers are the stakeholders of engineering management informatization. Through the case of airport management informatization, inherited and innovation of engineering management informatization will be discussed. It is illustrated that airport informatization is the innovation of business model and technology applications through the analysis and study on cases of airport informatization.

关键词： engineering management     informatization     inter-organizational relationship     management creation     resource sharing    

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Energy storage resources management: Planning, operation, and business model

《工程管理前沿（英文）》   页码 373-391 doi: 10.1007/s42524-022-0194-4

摘要： With the acceleration of supply-side renewable energy penetration rate and the increasingly diversified and complex demand-side loads, how to maintain the stable, reliable, and efficient operation of the power system has become a challenging issue requiring investigation. One of the feasible solutions is deploying the energy storage system (ESS) to integrate with the energy system to stabilize it. However, considering the costs and the input/output characteristics of ESS, both the initial configuration process and the actual operation process require efficient management. This study presents a comprehensive review of managing ESS from the perspectives of planning, operation, and business model. First of all, in terms of planning and configuration, it is investigated from capacity planning, location planning, as well as capacity and location combined planning. This process is generally the first step in deploying ESS. Then, it explores operation management of ESS from the perspectives of state assessment and operation optimization. The so-called state assessment refers to the assessment of three aspects: The state of charge (SOC), the state of health (SOH), and the remaining useful life (RUL). The operation optimization includes ESS operation strategy optimization and joint operation optimization. Finally, it discusses the business models of ESS. Traditional business models involve ancillary services and load transfer, while emerging business models include electric vehicle (EV) as energy storage and shared energy storage.

关键词： energy storage system     energy storage resources management     planning configuration     operational management     business model    

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Discussion on Problem-Based Engineering Management System

Qiao Xiang

《工程管理前沿（英文）》 2015年 第2卷 第3期   页码 249-260 doi: 10.15302/J-FEM-2015054

摘要： The paper puts forward the idea of problem-based engineering management, expounds its connotation and guiding ideology and moreover, substantially demonstrates its practical significance in the engineering management system for the maintenance of Chinese military aircraft engines.

关键词： problem     engineering management     system    

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Revealing Engineering Management System and Education Model in Developed Countries for Engineering Management

Jian-ya Jiang,Yang-wei Rao

《工程管理前沿（英文）》 2014年 第1卷 第4期   页码 406-409 doi: 10.15302/J-FEM-2014049

摘要： Different developed countries have differences in regulations for engineering management systems. The related education modes and their curriculum arrangement in universities in the US, UK, and Germany show their specializations. Through comparative research into engineering management systems and professional education modes between China and these developed countries, the paper proposes suggestions for improving the education of engineering management majors in China, which could speed up development of Chinese engineering general contracting enterprises and engineering project management enterprises.

关键词： engineering management system     education mode     comparative research     training improvement    

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Strengthening Project Management to Attain Overseas Blocks with High Potential for Exploration

Shu-lin Zhang

《工程管理前沿（英文）》 2016年 第3卷 第4期   页码 331-337 doi: 10.15302/J-FEM-2016058

摘要： New overseas venture evaluation is key for oversea exploration of Chinese oil companies, whose credibility directly determine the degree of success of exploration for overseas blocks. The uniqueness of new overseas venture evaluation in short assessing cycle and limited data make project management vital. Project management includes human resource allocation, quality control and effective communication. In China National Offshore Oilfield Corporation (CNOOC), the new overseas venture evaluation system has been established. This system includes quality control system and assurance for new overseas venture evaluation, geological evaluation norms for overseas oil & gas exploration, regulations for new overseas venture evaluation and seismic interpretation methodology and procedure for new overseas venture evaluation. Directed by the new overseas venture evaluation system, three-level quality control and management of data-room visit are strictly reinforced, which guarantees the efficiency and quality of new overseas venture evaluation. As a result the new overseas venture evaluation boosts the development of young explorationists and leads to breakthroughs in exploring potential target areas of CNOOC and in the discovery of giant oil and gas fields, which underpins the development of overseas business in CNOOC.

关键词： new overseas venture evaluation     exploration     project management     quality management     assessing system    

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标题 作者 时间 类型 操作

航空公司不正常航班管理——模型和解决方法综述

苏艺, 谢可欣, 王洪建, 梁哲, Wanpracha Art Chaovalitwongse, Panos M. Pardalos

期刊论文

Two-stage stochastic programming with robust constraints for the logistics network post-disruption response

期刊论文

Modeling of the resilient supply chain system from a perspective of production design changes

期刊论文

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

期刊论文

Enhanced production of

Shen Huang,Xudong Feng,Chun Li

期刊论文

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

null

期刊论文

Simultaneous harvesting and cell disruption of microalgae using ozone bubbles: optimization and characterization

Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee

期刊论文

Metro train rescheduling by adding backup trains under disrupted scenarios

Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU

期刊论文

Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption

期刊论文

The Routine and Emergency Coordinated Management of Public Security

Ning Liu

期刊论文

Inheritance and Innovation of Engineering Management Informatization

Kai Sun,Ren-huai Liu

期刊论文

Energy storage resources management: Planning, operation, and business model

期刊论文

Discussion on Problem-Based Engineering Management System

Qiao Xiang

期刊论文

Revealing Engineering Management System and Education Model in Developed Countries for Engineering Management

Jian-ya Jiang,Yang-wei Rao

期刊论文

Strengthening Project Management to Attain Overseas Blocks with High Potential for Exploration

Shu-lin Zhang

期刊论文